VITRO-SKIN® is an advanced testing substrate that effectively mimics the surface properties of human skin. It has been formulated to have topography, pH, critical surface tension, chemical reactivity and ionic strength that is similar to human skin.
VITRO-SKIN® is currently used by over 175 leading companies worldwide and has been referenced in numerous patents and scientific presentations. It has been successfully applied in a broad range of in vitro methods including the measurement of SPF and UVA protection factors, evaluation of the water resistance of sunscreen formulations, measuring the photo-stabilizing effects of raw material additives, rapid in vitro assessment of sunless tanning formulations, evaluation of the performance of skin adhesives and adhesive bandages (including waterproof bandages), in vitro microbiological testing (both antimicrobial and antivirus), in vitro skin deposition studies (of a broad range of functional materials and active ingredients) and assessment of prototype and emollient spreading. Testing done on VITRO-SKIN® is generally more reproducible than that performed on human skin due to the consistent topography and wetting properties across each sheet. VITRO-SKIN® with N-19 topography is optimized to mimic human back skin. It is a synthetic (non-biological) product.
At IMS, our mission is to generate highly predictive SPF and UVA data for our clients, rapidly and at modest cost. We do not offer dozens of different assays. Instead we have focused our research efforts on in vitro SPF and UVA testing both static and water resistance. We are committed to offering the highest quality data and the best possible service to our clients.
- For color comparisons
- To test make up removal properties of facial cleansers
- For lipstick pay-out, wear and durability evaluation
- Assess color development of prototype formulations and raw materials
- Easily follow color development via reflectance measurements (using a color probe)
Are you working to develop Suncare products that deliver superior waterproof performance? Are you responsible for developing new waterproof raw material and formulation technology? Do you wish that there was a rapid in vitro waterproof method that correlated with in vivo testing?
(VITRO-SKIN® vs. Transpore Tape)
- One IMS in vitro SPF/UVA testing protocol
- Two 22 cm x 27 cm (8.5″ x 10.5″) sheets of VITRO-SKIN®
- Four 6 cm x 6 cm sample holders
- Two 35 mm reference holders
- One plastic hydration chamber with two mesh shelves and a spacer
- One plastic covered foam block (to simulate the flexibility of the human dermis)
- Twelve latex finger cots
The quantity of water absorbed by human stratum corneum during product application, rub-out and dry-down impacts on how various emulsions spread and de-emulsify on skin. Our research indicates that water absorption by substrate (either human skin or VITRO-SKIN®) can have a significant effect on measured SPF and UVA protection factors. Dramatic improvements in the correlation with in vivo testing can be achieved by reproducibly hydrating the substrate prior to product application.
International Journal of Cosmetic Science, 2002, 24, 1-8
Development of an in vitro efficiency test for self-tanning formulations
R. Jerrmann, M. Toumiat and D. Imfeld
Pentapharm Ltd, Engelgasse 109, CH-4002 Basel, Switzerland
Received 20 April 2001. Accepted 26 July 2001.
Keywords: erythrulose, dihydrosyacetone, in vitro efficacy test, self-tanning formulations, skin colour assessment, vitro skin
Synopsis
In the last few years, the desire to acquire a tan without sunbathing has grown. In response, many cosmetic companies have produced self-tanning preparations. However, to optimize these formulations, a suitable model to assess the colour induced on the skin remains to be developed. We have developed an in vitro method using a synthetic skin in order to study the efficacy of self-tanning formulations. The in vitro test was then used to study the influence of cosmetic ingredients upon the colour induced by erythrulose- or dihydroxyacetone-containing formulations. Finally, an in vivo study allowed us to relate the results obtained in vitro with those found on human skin. The results show that this in vitro test system is a reliable tool to predict the efficacy of self-tanning products.
PROCEEDINGS OF THE 20TH IFSCC CONGRESS
USE OF SYNTHETIC SKIN FOR IN-VITRO EVALUATION OF PHOTPROTECTIVE EFFICACY OF SUNSCREENS: APPLICATION TO DIFFERENT TYPE OF EMULSIONS
N.S. Tokgoz, G. Marginean-Lazar, A. Ponte, A.E. Fructus
Laboratoires Dermatologiques Lutsia, Boots Healthcare International, Paris, France 2Hermal, Boots Healthcare International, Hamburg, Germany 3Ecole Biolgie Industrielle, Paris, France
Several methods exist that evaluate sunscreens efficacy for ultraviolet radiations (FDA, DIN, COLIPA, Australian standards etc.) and it is generally accepted that the determination of sun protection faction (SPF) on humans is the most reliable one.
PROCEEDINGS OF THE 20TH IFSCC CONGRESS
SUNSCREEN O1/W/O2, MULTIPLE EMULSION WITH ORGANIC AND MINERAL UV ABSORBERS.
L. Ferrero, K. Golz, S. Bouttes, L. Zastrow
INTRODUCTION:
Numerous studies have revealed the interest of multiple emulsions for the cosmetic industry (1)-(4). These complex systems present several advantages compared to other systems: high entrapment capacity, possible protection of fragile substances encapsulated into the internal
PROCEEDINGS OF THE 20TH IFSCC CONGRESS
SPECTROSCOPY OF SUNSCREEN PRODUCTS: HOW TO EXPLAIN THE SPECIAL SHAPE OF UV CURVES OBTAINED FROM IN VITRO SPF TESTS.
Authors: L. Ferrero, A.M. Orcet, L. Zastrow
INTRODUCTION:
Numerous attempts have been made to understand how sunscreen preparations protect against UV radiations (1)-(4). Normally, the final UV absorption of a sunscreen product should depend on absorption curves of each UV filters placed within the preparation. However, it is now trivial to remark the bad accordance between SPF(s) directly calculated from spectroscopic absorbances of pure UV filters (obtained from dilute solutions and measured in 1 cm quartz
PROCEEDINGS OF THE 20TH IFSCC CONGRESS
RHEOLOGICAL PROPERTIES AND FUNCTIONALITY OF SUNSCREEN FORMULATIONS
A. Semenzato, M. Poropat, M. Marcazzan, A. Bettero
Centro di Cosmetologia Chimica, Dipartimento di Scienze Farmaceutiche, Universita di Padova Via Marzolo 5, 35131 Padova, Italy
INTRODUCTION:
The use of polymeric additives as raw materials 1, 2, 3, 4, which could increase the SPF value of sunscreens, has grown up much lately.
PROCEEDINGS OF THE 20TH IFSCC CONGRESS
COMPARISON OF UVA/UVB PROTECTION OF FOUNDATION FORMULATIONS BETWEEN SPHERICAL POLYMER MATRIX COMPOSITES VERSUS NANOFINE METAL OXIDES ARE EVALUATED IN TWO SPF IN VITRO METHODS.
Jaana Printz and Alain Saintrond*
Cosmetic Innovations and Technologies, 13 Rue des Livraindrieres, Dreux, France.
*Creations Couleurs, Research Laboratory, 6 rue Jules Pasdeloup, 28100 Dreux, France.
Key Words: Colour stability, Photostability, Spherical Polymer Matrix Composites, In vitro SPF
Our No Hassle, 100% Satisfaction Guarantee: If for any reason you are not completely satisfied with the data you obtain using VITRO-SKIN®, VITRO-NAILS® or VITRO-CORNEUM®, simply return the unused substrate within 45 days for an immediate refund or credit.
- September 2015 – SCC Sunscreen Symposium – Invited Speaker (Orlando, FL)
- April 2002 – SCC Sunscreen Symposium – Short Course, A Unified Theory of Sunscreen Performance on Skin (Orlando, FL)
- September 1999 – SCC Sunscreen Symposium – Invited Speaker (Orlando, FL)
- September 1999 – SCC Sunscreen Symposium – UVA Short Course (Orlando, FL)
- September 1999 – Long Island Chapter SCC – Annual Educational Seminar – Invited Speaker (Melville, NY)
- February 1999 – Ohio Valley Chapter SCC – Invited Speaker (Cincinnati, OH)
- September 1998 – Prior to 20th IFSCC Congress – UVA Short Course (Cannes, France)
- September 1997 – SCC Sunscreen Symposium – UVA Short Course (Miami, FL)
- March 1997 – International Broad Spectrum Meeting – Invited Speaker (London, England)
- November 1996 – Photoprotection Short Course for the Australian SCC (Sydney, Australia)
- October 1996 – IFSCC Sunscreen Workshop – Invited Speaker (Sydney, Australia)
- October 1996 – IFSCC 1st Runner up for Outstanding Poster (Sydney, Australia)
- October 1995 – SCC Sunscreen Symposium – UVA Short Course (Orlando, FL)
- May 1995 – National SCC Scientific Seminar – Invited Speaker (Cleveland, OH)
- April 1995 – Mid-Atlantic Chapter SCC – Invited Speaker (Baltimore, MD)
- March 1995 – International UVA Meeting – Invited Speaker (London, England)
- November 1994 – Photoprotection Short Course for Raw Material Suppliers (Newark, NJ)
- September 1994 – Connecticut Chapter SCC – Invited Speaker (Westport, CT)
- June 1994 – World Short Course – 2 day Sunscreen Seminar (Newark, NJ)
- June 1994 – World Short Course – 2 day Sunscreen Seminar (Sydney, Australia)
- June 1994 – World Short Course – 2 day Sunscreen Seminar (London, England)
- May 1994 – FDA Meeting – UVA Claims and Testing Procedures for OTC Sunscreen Drug Products – Speaker (Rockville, MD)
- December 1993 – 2 day Photoprotection Short Course – Radisson Hotel (Newark, NJ)
- December 1993 – 2 day Photoprotection Short Course – Ritz Carlton Hotel (Marina del Rey, CA)
- October 1993 – SCC Sunscreen Symposium – Invited Speaker (Orlando, FL)
Patent# | Description | Company |
9,926,470 | Hybrid Material of Crosslinked Microgel Particles Dispersed in an Adhesive | Avery Dennison Corporation |
9,826,877 | Gel Wipe Composition Comprising a Superabsorbent Gel Fiber | Johnson & Johnson Consumer Inc. |
9,751,063 | Emulsion Compositions and Applications Therefor | Momentive Performance Materials Inc. |
9,669,243 | Delivery Of Hydrophobic Benefit Agents From Bodywashes And The Like Onto A Keratinous Substrate | BASF SE (Ludwigshafen, DE) |
9,622,944 | Gel-Wipe For Personal Care And Household Cleansing | Johnson & Johnson Consumer Inc. |
9,561,164 | High Lubrication Shaving Aid | Kulesza; John E. |
9,486,396 | Metal Salt Compositions | Colgate-Palmolive Company |
9,468,614 | Oral Care Method And Kit | 3M Innovative Properties Company |
9,370,475 | Oral Care Compositions | Colgate-Palmolive Company |
9,216,304 | Method Of Depilation And Depilatory Kit | The Gillette Company |
9,044,403 | Sporicidal Hand Sanitizing Lotion | Medivators Inc. |
8,986,663 | Skin Care Compositions | Rohm and Haas Company & Union Carbide Chemicals & Plastics Technology LLC |
8,568,701 | Cationic Synthetic Polymers With Improved Solubility And Performance In Phosphate Surfactant-Based Systems And Use In Personal Care And Household Applications | Hercules Incorporated |
8,557,229 | Hair Removal Method And Hair Removal Kit | The Procter & Gamble Company |
8,545,859 | Use Of Acrylates Copolymer As Waterproofing Agent In Personal Care Applications | Akzo Nobel N.V. |
8,460,689 | Oral Care Method And Kit | 3M Innovative Properties Company |
8,343,523 | Disinfectant With Durable Activity Based On Alcohol-Soluble Quaternary Ammonium Polymers And Copolymers | Quick-Med Technologies, Inc. |
8,343,469 | Cationic Synthetic Polymers With Improved Solubility And Performance In Surfactant-Based Systems And Use In Personal Care And Household Applications | Hercules Incorporated |
8,318,220 | Bioactive Compositions From Theacea Plants And Processes For Their Production And Use | Akzo Nobel Surface Chemistry LLC |
8,263,678 | Compositions For Repelling Fluid And Uses Thereof | McNeil-PPC, Inc. |
8,173,110 | Pre-Shave Preparation With Enhanced Lubricity | Combe Incorporated |
8,158,678 | Photoabsorbing, Highly Conjugated Compounds Of Cyanoacrylic Esters, Sunscreen Compositions And Methods Of Use | CPH Innovations Corp. |
8,088,400 | Disinfectant With Quarternary Ammonium Polymer And Copolymers | Quick-Med Technologies, Inc. |
8,043,635 | Bioactive Compositions From Theacea Plants And Processes For Their Production And Use | Akzo Nobel Surface Chemistry LLC |
7,981,402 | Alkyl Benzene Sulfonyl Urea Photostabilizers And UV-Absorbers | Hallstar Innovations Corp. |
7,799,317 | Photostabilizers, UV Absorbers, And Methods Of Photostabilizing Compositions | Hallstar Innovations Corp. |
7,648,697 | Compounds Derived From Polyanhydride Resins With Film-Forming, UV-Absorbing, And Photostabilizing Properties, Compositions Containing Same, And Methods Of Using The Same | Hallstar Innovations Corp. |
7,560,098 | Compounds Derived From Polyanhydride Resins With Film-Forming, UV-Absorbing, And Photostabilizing Properties, Compositions Containing Same, And Methods Of Using The Same | Hallstar Innovations Corp. |
7,550,134 | Compounds Derived From Polyanhydride Resins With Film-Forming, UV-Absorbing, And Photostabilizing Properties, Compositions Containing Same, And Methods Of Using The Same | Hallstar Innovations Corp. |
7,534,420 | Compounds Derived From Polyanhydride Resins With Film-Forming, UV-Absorbing, And Photostablizing Properties, Compositions Containing Same, And Methods Of Using The Same | Hallstar Innovations Corp. |
7,473,435 | Bioactive Compositions Form Theacea Plants And Processes For Their Production And Use | Integrated Botanical Technologies, LLC |
7,179,880 | Cosmetic Preparation Containing Polycarbonates | Cognis Deutschland GmbH & Co. KG |
7,014,842 | Sunscreen Composition | Playtex Products, Inc. |
6,991,799 | Non-Sticky Cosmetic Moisturizer For Skin And Hair | Unilever Home & Personal Care USA division of Conopco, Inc. |
6,770,270 | Methods Of Making And Selling A Sunscreen Composition | The C.P. Hall Company |
6,576,228 | Personal Wash Sunscreen Compositions Which Deposit And Lather Well | Unilever Home & Personal Care USA division of Conopco, Inc. |
6,537,529 | Sunscreen Compositions And Methods And Materials For Producing The Same | The C.P. Hall Company |
6,485,713 | Sunscreen Compositions And Methods And Materials For Producing The Same | The C. P. Hall Company |
6,406,682 | Saxifraga Extracts For Artificially Tanning Human Skin | Societe L’Oreal |
5,849,273 | Skin Care And Sunscreen Composition Containing Dibenzoylmethane Derivative, E.G., Parsol.RTM. 1789, And C.Sub.12, C.Sub.16, C.Sub.18 Branched Chain Hydroxybenzoate And/Or C.Sub.12, C.Sub.16 Branched Chain Benzoate Stabilizers/Solubilizers | The C. P. Hall Company |
5,788,954 | Hydrating Skin Care And Sunscreen Composition Containing Dibenzoylmethane Derivative, E.G., Parsol 1789, And C12, C16, C18 Branched Chain Hydroxybenzoate And/Or C12, C16, Branched Chain Benzoate Stabilizers/Solubilizers | The C. P. Hall Company |